Alzheimer’s: Implication of Sugar is Confirmed

Alzheimer’s: Implication of Sugar is Confirmed

Healthy people who have a diet high in sugars and foods with high glycemic index have more amyloid plaques in the brain, increasing their risk of dementia later. It’s not too late to change.

A new study published in the American Journal of Clinical Nutrition shows that in people without cognitive impairment, a diet high in sugars and foods with high glycemic index increases the amount of amyloid plaques in the brain, increasing the risk of progression to Alzheimer’s disease.

Why this study concerns us

Alzheimer’s disease is associated with a significant accumulation of amyloid plaques in the brain, although it is unclear whether it acts more as a cause or consequence of the disease. ” In people with no cognitive impairment, 20% to 40% of cases have cerebral amyloid deposits, which increases their risk of developing Alzheimer’s disease, ” the researchers say. They have a higher risk of cerebral atrophy. ” These people are also the subject of intervention studies to try to prevent or delay the onset of Alzheimer’s disease with a particular interest in lifestyle factors such as diet .”

Current studies show that impaired glucose metabolism and hyperglycemia are associated with a higher risk of Alzheimer’s disease. ” For example, people with type-2 diabetes and high blood sugar have a higher risk of dementia and have a faster progression from mild cognitive impairment to Alzheimer’s disease .”

In addition, a recent study showed that a fasting glucose abnormality was associated with an increase in amyloid load in the brain in a population of adults with normal cognitive abilities.

What the researchers found

The type of carbohydrate and its amount have a strong impact on glucose metabolism. The researchers therefore wanted to study in a population of 128 adults over the age of 65 and without cognitive impairment, the relationship between food intakes known to modify blood glucose and the presence of amyloid plaques, evaluated by an imaging technique. molecular.

The results show that people who have high intakes of sugars and carbohydrates and a diet with high glycemic load also have a higher level of amyloid plaques in the brain. Participants with the highest intakes of sugars overall had the lowest cognitive performance. “. These results show the importance of diet to prevent Alzheimer’s disease. Previous studies have shown a relationship between other nutrients and the presence of amyloid plaques. For example, higher intakes of vitamin B12, vitamin D, zinc and omega-3 are associated with fewer amyloid plaques.

In practice

This study confirms that in order to maintain the body in a global state of health, care must be taken, among other things, of the quality of the carbohydrates that are therefore best consumed, and adjust the quantities consumed to the level of physical activity. LaNutrition has recommended from the beginning to go for low to moderate glycemic index foods, to limit sweet foods and ultra-processed foods (which account for 90% of added sugars).


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