Coffee, Dandelion, Fatty fish: They Make War On Beads

Coffee, Dandelion, Fatty fish: They Make War On Beads

Natural substances can act on the adipose tissue where the fats of the organism are stored.

Coffee, Dandelion, Fatty fish They Make War On Beads

Adipose tissue changes over time: adipocytes (fat cells) form, others die by apoptosis or programmed death. Natural substances can influence these processes and help to slim down. For example, anti-obesity molecules act by decreasing the differentiation of pre-adipocytes into adipocytes, proliferation, or by increasing energy expenditure and lipolysis (lipid destruction).

Outside coffee, here are two promising tracks.


Dandelion is used in traditional medicines to treat liver problems, digestion and for its diuretic properties. It also has anti-inflammatory, anti-oxidant, anticancer, analgesic, anti-hyperglycaemic and anti-coagulant effects.

In an article in June 2016, Italian researchers tested the effects of different natural compounds on adipocytes: Silybum marianum , Citrus aurantium (bitter orange), Taraxacum officinale (dandelion), Resveratrol, Curcuma, Caffeine, Oleuropein (Present in olive oil) and DHA (an omega-3). They wanted to know if these extracts could reduce the differentiation of adipocytes and increase lipolysis or apoptosis.

Of all these bioactive compounds, dandelion extract was most effective in inducing apoptosis of pre-adipocytes (cells to be differentiated into adipocytes). Caffeine and DHA were the most effective in inhibiting differentiation and inducing lipolysis.

An Omega-3: DHA

DHA is an omega-3 fatty acid found in fatty fish.

In plants, there is alpha-linolenic acid (ALA), an omega-3 which in the body becomes a source of DHA. For example, flax seeds, nuts, are rich in ALA.

American researchers have elucidated the mechanism by which DHA exerts its anti-obesity effects. Experimental studies have already shown that omega-3 supplements decrease body fat in rodents.

This time, Hye-Kyeong Kim and his team from the University of Georgia (Athens) observed what happens when DHA is added at variable concentrations to cell cultures – pre-adipocytes – that give rise to adipocytes. DHA causes the programmed death of these cells (apoptosis). In addition, DHA reduces the accumulation of fat in pre-adipocytes: the more DHA, the less fat accumulates. DHA also inhibits the transformation of pre-adipocytes into adipocytes, mature fat cells.

We recommend eating up to 2 to 3 servings of oily fish per week (or equivalent: shellfish, crustaceans …) if you are omnivorous but not more than 2 servings during pregnancy and in children by choosing poorly contaminated and non-threatened species. For vegetarians: eating chicken eggs fed on flaxseed and consuming flaxseed, chia seed, nuts, rapeseed and flaxseed oil with little omega-6 fatty acids ( Avoid sunflower, corn, grape seed oils, and excess corn, grain products). For vegans: same advice, but without the eggs of course.


Colitti M, Stefanon B. Different anti-adipocyte effects of a pre-adipocytes and adipocytes. EXCLUDED J. 2016 Jun 20, 15: 362-77. Doi: 10.17179 / excli2016-267

Hye-Kyeong Kim, MaryAnne Della-Fera, Ji Lin, and Clifton A. Baile;Docosahexaenoic Acid Inhibits Adipocyte Differentiation and Induces Apoptosis in 3T3-L1 Preadipocytes. J. Nutr. 2006 136: 2965-2969.


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